Biostatistics Core Facility

Overview

A strong research design and biostatistics support play a critical role in the long-term success of clinical and translational research and education enterprises. Current research studies involve complex study design and generate complicated multivariate data, which require biostatistics expertise. The Biostatistics Core Facility under the Department of Quantitative Health Sciences provides biostatistical research support to basic science, clinical, and translational investigators. The core specializes in study design, data health management and data analysis, participates in grant proposal development, conducts methodology research, and provides education in biostatistics and other related areas.

JABSOM medical trainees (i.e., medical students, residents or fellows): If you meet the following criteria,

  • You are the Principal Investigator (PI) of this research project
  • You will be the first author of forthcoming publications related to this research project

and agree to the following:

  • The biostatistical consultant and the supervising Biostatistics Core Facility faculty member, if any, will be listed as co-author(s) on all resulting publications, presentations, abstracts, and posters if significant intellectual contributions were made.
  • The following acknowledgment will be included in all publications and presentations as a result of the consulting services provided: The project described was supported by the Office of the Dean through the Barry & Virginia Weinman Endowment. XXX (Individual biostatistician(s)) was (were) partially supported by the U54MD007601 (Ola HAWAII) and U54MD007584 (RMATRIX) grants from the National Institute of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH."

you can directly schedule a consultation appointment through the Medical Trainee Consultation Calendar. Do not submit a separate JABSOM Biostatistics Core Facility request form.

For all other requests, please fill out the form below:

Services

The faculty and staff Biostatistics Core Facility are ready to provide high-quality, efficient, and reliable biostatistics collaboration and support services to promote excellence in education and research:

Consultations & Fee-for-Service Projects

We provide a free initial consultation for each research project. The initial consultation provides a perfect opportunity for researchers to explore ideas/hypotheses, and to discuss study feasibility with Biostatistics Core Facility faculty and/or staff.

For short-term or non-extramurally funded projects, we offer biostatistical support through a fee-for-service basis. Biostatistics Core Facility faculty and staff provide research design, database design and management, data analysis, and results interpretation and dissemination services to research and education projects funded by the investigator's department funds or other sources.

Data Analysis

Biostatistics Core Facility faculty and staff provide comprehensive biostatistics data analysis as listed below:

  • Data coding and management
  • Comprehensive univariate and multivariate analyses
  • Data and safety monitoring, including interim analyses
  • Large healthcare data analytics
  • Tailored statistical tool development to address specific research questions and challenges

Grant Proposal & Development

To encourage and facilitate more research activities at JABSOM and its affiliated institutes, the Biostatistics Core Facility will provide research design and data analysis plan support and expertise in the development of extramural grant proposals. Excluding extensive preliminary data analysis, the support is currently free of charge as long as an adequate percentage FTE of the participating faculty and staff is built into the grant budget.

As grant application deadlines tend to be clustered around certain dates, please contact us well before the deadline so we will be able to properly support your grant application and increase your chance of obtaining funding.

Research Design

A strong research design is critical for basic science, clinical and translational research. The involvement of experienced biostatistics specialists in the development of a research project tends to significantly increase the quality of an investigation. Funding agencies and study sessions are focusing more on the research design of a proposed study to ensure the design is optimal. Biostatistics Core Facility faculty and staff members have research design expertise in the following areas:

  • Research feasibility discussion to establish testable research hypothesis
  • Sample size and statistical power determination
  • Data-instrument development, such as questionnaires
  • Data-coding protocols
  • Sampling procedures
  • Study design and statistical analysis plan development for grants

Note: To help increase the likelihood of obtaining extramural funding, Biostatistics Core faculty and staff need sufficient time to customize the research design and data analysis sections for your individual research proposal. We strongly recommend that you contact us as early as possible, at least several weeks before the submission deadline.

Database Development & Management

Database Development & Management involves the use of information technology interventions for clinical and translational research projects. The Biostatistics Core Facility has experience in various areas, including:

  • Database design and programming
  • Large healthcare data management
  • Web application development

Results Dissemination

The BQHS faculty and staff have extensive experience with results presentation and dissemination, such as:

  • Biostatistics results interpretation
  • Results presentations (e.g., figures, tables) for manuscripts and posters
  • Biostatistics methodology and results sections development for reports and manuscripts

Note: Authorship is generally expected on scientific journal articles or presentations, where substantial efforts on research design and/or data analysis are provided. Reimbursement for Biostatistics Core Facility support (either through %FTE or fee-for-service) does not preclude or replace authorship.

Policy

I. Timeline Policy

Biostatisticians usually work on multiple projects at a given time. Sufficient time will be needed for the biostatistician to appropriately address your needs before your deadline. Please allow adequate lead-time when contacting the core facility for assistance. Below are the minimum times needed to complete types of biostatistical support requests:

Protocol development/ grant application/re-submission – at least 4 weeks to provide tailored input from the biostatisticians.

Data analysis project – at least 2 weeks after receiving the data. Depending on the quality and complexity of data analysis, etc., more time may be required.

REDCap database development project – at least 2 weeks after the discussion on project specifications. Depending on complexity of form structure, more time may be required.


Size of the project Examples of service requests & what activities may be involved Hours estimation guidelines
Brief
  • Research design, including sample size estimation
  • Data analysis advice and input
  • REDCap Database implementation for less than five forms
<5
Short
  • REDCap Database design and implementation for less than seven forms, or implementation for less than 15 forms
  • Abstracts: descriptive statistics and/or univariate inference analysis
  • Pilot data analysis for grant application
  • Manuscript review and advice (addressing reviewer’s comments)
5-15
Medium
  • Abstracts require multivariable modeling
  • REDCap Database design and implementation for more than 20 forms, projects that require medium-complex linking implementation (e.g., longitudinal projects with multiple years and events and/or multi-dimensional projects), or projects that require features not included in standalone REDCap (e.g., Dynamic SQL, API, Data Entry Trigger, etc)
16-39
Long
  • Statistical analysis for regular scientific manuscripts, including figures/tables and write-up
  • Complex REDCap implementations requiring features outside of standalone REDCap (e.g., Dynamic SQL, API, Data Entry Trigger, etc.); application-level relational database development (e.g., databases held on a standalone website)
>40

II. Authorship Policy

It is our Core’s policy that the biostatisticians who contribute to the study design and/or conduct the data analysis will be qualified as co-authors on the publication/abstract/presentation to acknowledge their scientific and intellectual contribution to the work. It should be clear that funding/fees for time does not preclude or replace authorship. Consideration for authorship should be based on the contribution of each person and on the accepted criteria for most medical journals. These criteria generally cite both study design and statistical analysis as intellectual input sufficient for authorship. For more information, please refer to the International Committee of Medical Journal Editors (ICMJE) Authorship guidelines (www.icmje.org).


III. Grant Acknowledgement Policy

The JABSOM Biostatistics Core Facility is a research facility partially supported by several institutional infrastructure grants. Acknowledgement of such grants in all publications or presentations resulting from the utilization of biostatistics core services is required. The grant should be acknowledged in the following format: “XXX (Individual biostatistician(s)) was (were) partially supported by the U54MD007601 (Ola HAWAII) and U54MD007584 (RMATRIX) grants from the National Institute of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH.”


IV. Request for Resources

Investigators should request resources or consultations from the Biostatistics Core Facility by using the Request for Resources online form.


V. Fee Structure

Our service is free for brief consultations (about an hour). Additional hours can be requested on a recharge basis. We offer biostatistical support through a fee-for-service basis. A project-based collaborative agreement can be established, which is a cost-effective and efficient approach to ensure comprehensive and stable analytic support for your project. The Biostatistics Core Facility faculty and staff can provide collaborative support through either a percentage of full-time equivalent (FTE) salary recovery mechanism or a negotiated collaborative agreement.

We provide up to 20 hours of free of charge support toward extramural grant proposal development that include salary support for biostatistics faculty/staff at 10% FTE and above. This option is appropriate for research projects that would benefit from significant involvement of a biostatistician, usually as a coinvestigator or key personnel, both while writing the grant and once it is funded. Many grant applications are strengthened and prospects for funding improved by collaborating with a biostatistician(s) on the proposal.

Biostatistics Core Facility Rate for University of Hawaii (effective date July 1, 2019):

Faculty Statistician:
$120 per hour
Staff Statistician:
$80 per hour
Staff Programmer:
$80 per hour

The following re-charge algorithm is provided as a general guideline:


Projects led by University of Hawaii Junior Researchers as Principal Investigators (PIs) (Assistant Professor or below) who currently receive pilot funding (<$100k) from UH infrastructure grants 25% of Core rate
Health disparity studies with University of Hawaii researchers as PIs 50% of Core rate
Non-health disparity studies by University of Hawaii Investigators Full Core rate
Pharmaceutical studies; non-UH external projects Please contact: biostat@hawaii.edu

VI. JABSOM Medical Trainees

With allocated funding from the Dean’s Office, JABSOM medical trainees (i.e. medical students, residents or fellows) may have access to free biostatistical support. If you are a JABSOM medical trainee and meet the following criteria: (1) PI of your research project and (2) first author of forthcoming publications related to your research project, you can schedule a consultation through the Medical Trainee Consultation Calendar (https://qhs.jabsom.hawaii.edu/biostatistics-core/consulting/). Do not submit a separate JABSOM Biostatistics Core Facility request form.

The biostatistical consultant and the supervising/supporting Biostatistics Core Facility faculty member, if any, will be listed as co-author(s) on all resulting publications, presentations, abstracts, and posters if significant intellectual contributions were made.

The following acknowledgement will be included in all publications and presentations as a result of the consulting services provided: The project described was supported by the Office of the Dean through the Barry & Virginia Weinman Endowment. XXX (Individual biostatistician(s)) was (were) partially supported by the U54MD007601 (Ola HAWAII) and U54MD007584 (RMATRIX) grants from the National Institute of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH."

If you have any questions please contact the Biostatistics Core Facility at biostat@hawaii.edu

Members


John Chen, Ph.D. | Professor and Chair; Director, Biostatistics Core Facility
Email: jjchen@hawaii.edu
Phone: (808) 692-1814


Eunjung Lim, Ph.D. | Assistant Professor
Email: lime@hawaii.edu
Phone: (808) 692-1817


Hyeong Jun Ahn, Ph.D. | Assistant Professor
Email: hjahn@hawaii.edu
Phone: (808) 692-1822


James Davis, Ph.D., M.S. | Associate Professor
Email: jamesdav@hawaii.edu
Phone: (808) 692-1806


Chathura Siriwardhana, Ph.D. | Assistant Professor
Email: cksiri@hawaii.edu
Phone: (808) 692-1487


So Yung Choi, M.S. | Biostatistical Analyst
Email: soyung@hawaii.edu
Phone: (808) 692-1823


Breanna Morrison, Ph.D. | Biostatistical Analyst
Email: bmmorris@hawaii.edu
Phone: (808) 692-1815


Masako Matsunaga, Ph.D. | Graduate Research Assistant
Email: mmatsuna@hawaii.edu
Phone: (808) 692-1419


Munirih Taafaki, M.S., C.C.R.P. | Manager, Biostatistics Core Facility
Email: mtaafaki@hawaii.edu
Phone: (808) 692-1812


Meliza Roman, B.A. | Biostatistics Core Research Project Associate
Email: melizar@hawaii.edu
Phone: (808) 692-1466


Jason Delos Reyes, B.S. | Application Programmer
Email: jdelosr@hawaii.edu
Phone: (808) 692-1481

Request for Services

JABSOM medical trainees (i.e., medical students, residents or fellows): If you meet the following criteria,

  • You are the Principal Investigator (PI) of this research project
  • You will be the first author of forthcoming publications related to this research project

you can directly schedule a consultation appointment through the Medical Trainee Consultation Calendar. Do not submit a separate JABSOM Biostatistics Core Facility request form.

For all other requests, please fill out the form below to help us better coordinate our support and meet your specific needs.

If your request is related to a project supported by an organization with a partnership agreement with JABSOM Biostatistics Core Facility, please let us know in your request.

Seminars/Workshops

We have provided over 50 seminars and workshops to over a dozen departments/institutes in the past five years with a variety of statistical topics including basic biostatistics, clinical and translational research using big data, research design, and bioethics in statistics. Our faculty members have mentored visiting scholars, students, and trainees, and have served as thesis and dissertation committee members of graduate students from across campus.

Our experienced faculty and staff at the Biostatistics Core Facility provide the following mentoring and training:

  • For-credit biostatistics courses of various levels of difficulty (please see Education for details)
  • Biostatistics workshops and seminars for trainees (graduate students, residents, fellows), faculty, and staff
  • Serving as biostatistics mentors for students and trainees

Note: For upcoming seminars or workshops, please contact us for details.

Publications

If you utilize the Biostatistics Core Facility in publications, abstracts, posters, and oral presentations, please insert the following acknowledgement as a result from the services provided to you:

"XXX (Individual biostatistician(s)) was (were) partially supported by the U54MD007601 (Ola HAWAII) and U54MD007584 (RMATRIX) grants from the National Institute of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH."


List of Selected Publications


  • Panizza CE, Boushey CJ, Delp EJ, Kerr DA, Lim E, Gandhi K, Banna JC. Characterizing early adolescent food waste using the mobile food record. Nutrients. 2017 Jan;9(93):1-10. doi:10.3390/nu9020093.

  • Lim E, Gandhi K, Davis J, Chen JJ. Prevalence of chronic conditions and multimorbidities in a geographically defined geriatric population with diverse races and ethnicities. Journal of Aging and Health. 2016 Dec;doi:10.1177/0898264316680903. PubMed PMID: 27913765.

  • Kumar M, Ching L, Astern J, Lim E, Stokes AJ, Melish M, Nerukar VR. Prevalence of antibodies to zika virus in mothers from Hawaii who delivered babies with and without microcephaly between 2009-2012. PLOS Neglected Tropical Diseases. 2016 Dec;10(12):1-8. doi:10.1371/journal.pntd.0005262. PubMed PMID: 27997547.

  • Sentell T, Ahn HJ, Miyamura J, Taira DA. Thirty-day inpatient readmissions for Asian American and Pacific Islander subgroups compared with Whites. Medical Care Research and Review. 2016 Nov;doi:10.1177/1077558716676595.

  • Fukunaga BT, Sumida WK, Taira DA, Davis JW, Seto TB. Hospital-acquired methicillin-resistant staphylococcus aureus bacteremia related to medicare antibiotic prescriptions: a state-level analysis. Hawaii Journal of Medicine & Public Health. 2016 Oct;75(10):303-309. PubMed PMID: 27738564; PubMed Central PMCID: PMC5056633.
Biostatistics Core

University of Hawaiʻi John A. Burns School of Medicine
651 Ilalo Street
Medical Education Building, Suite 411
Honolulu, HI 96813

Director: John Chen, Ph.D.
Phone: (808) 692-1814
Email: biostat@hawaii.edu

Manoa

651 Ilalo Street, Medical Education Building, Suite 411, Honolulu, HI 96813

Phone: 808.692.1840 / Email: qhs@hawaii.edu

JABSOM

© Department of Quantitative Health Sciences, University of Hawaii John A. Burns School of Medicine