Services

The Bioinformatics Core Facility provides the following services in hopes of building and maintaining an infrastructure that enables the applications of strong informatics solutions:

Consultation
Data Analysis
Grant Support
Data Management Service
Collaborative Research

Consultation
Experimental Design and Power Calculations – We highly encourage you to consult our bioinformatician prior to experiments to find a solution that fits your needs and budget. We will help design your experiments to obtain maximum leverage and perform data quality control checks for high-throughput data projects. Liaison with vendors: We will help identify the right product to ensure the quality of your research.

Consultation

Experimental Design and Power Calculations – We highly encourage you to consult our bioinformatician prior to experiments to find a solution that fits your needs and budget. We will help design your experiments to obtain maximum leverage and perform data quality control checks for high-throughput data projects.

Liaison with vendors: We will help identify the right product to ensure the quality of your research.

Data Analysis
AI and Machine Learning Next Generation Sequence Analysis Assembly and gene annotation DNA-Seq RNA-Seq including fusion gene and LncRNA Small RNA-Seq Chip-Seq Target-Seq Meth-Seq Metagenomics Microarray data analysis Gene expression Exon array for alternative splicing SNP array, GWIS miRNA array DNA methylation array CNV Proteomics data and Protein array Protein mass-spec data for protein expression and interaction Phosphor-screen Glycol-screen PTM (post translation modicication) Profilling Metobolomics data analysis Lipidomics Sugar profiling Entire metabolomics data analysis Multivariate biomarker identification and classification Feature selection algorithms Classification algorithms Gene pattern, function analysis, systems biology Gene and sample correlation and clustering analysis Gene enrichment analysis Gene ontology and pathway analysis Gene network analysis Integrative “omics” data analysis Image data analysis Single Cell Sequencing Nanostring Data Analysis

Data Analysis

- AI and Machine Learning
- Next Generation Sequence Analysis
  - Assembly and gene annotation
  - DNA-Seq
  - RNA-Seq including fusion gene and LncRNA
  - Small RNA-Seq
  - Chip-Seq
  - Target-Seq
  - Meth-Seq
  - Metagenomics
- Microarray data analysis
  - Gene expression
  - Exon array for alternative splicing
  - SNP array, GWIS
  - miRNA array
  - DNA methylation array
  - CNV
- Proteomics data and Protein array
  - Protein mass-spec data for protein expression and interaction
  - Phosphor-screen
  - Glycol-screen
  - PTM (post translation modicication) Profilling
- Metobolomics data analysis

- - - Lipidomics
    - Sugar profiling
    - Entire metabolomics data analysis

Multivariate biomarker identification and classification
- Feature selection algorithms
- Classification algorithms
Gene pattern, function analysis, systems biology
- Gene and sample correlation and clustering analysis
- Gene enrichment analysis
- Gene ontology and pathway analysis
- Gene network analysis
- Integrative “omics” data analysis
Image data analysis
Single Cell Sequencing
Nanostring Data Analysis

Grant Support
We will provide hardware and software support for UH researchers who plan to conduct preliminary data analysis for hypothesis development and testing as part of grant proposal writing. We will provide necessary guidance to include computational biological methods to analyze data in your research analysis plan. Letters of support for your grant proposal can be prepared upon request.

Data Management Service
We will provide data management services and develop a web-based database for collection, storage, integration, and management of clinical data and scientific research data.

Collaborative Research
We are involved in collaborative research of several principal investigators from different UH departments and campuses. We perform bioinformatics data analysis by running routine bioinformatics applications and custom programs developed specifically to fulfill our research objectives.